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Scrapie and scrapie-related pathology in rodent models
Reference
BBS/E/I/00000634
Principal Investigator / Supervisor
Mrs Patricia McBride
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
315,396
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/03/2003
Duration
72 months
Abstract
The pathogenesis of disease following oral challenge of hamsters with the 263K scrapie strain is being investigated. The spread of TSE infection from sites of uptake in the gut is being traced using accumulation of disease associated forms of PrP as a surrogate marker for infectivity. The timing and sequence of PrP accumulation in the gut, lymphoid tissues, peripheral nervous system and central nervous system are being investigated using immunocytochemistry. This will indicate, not only which tissues become involved, but also the particular cells that are affected within these tissues. An important part of this project is to trace the neuroanatomical spread of infection from the periphery to the central nervous system.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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