Award details

Peripheral pathogenesis of scrapie

Reference	BBS/E/I/00000633
Principal Investigator / Supervisor	Dr Moira Bruce
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	240,295
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/2003
Duration	72 months

Abstract

In this project we are investigating issues relevant to pathogenesis of TSEs after peripheral exposure and the potential for intervention in mouse TSE models. We are investigating PrP expression in peripheral tissues of uninfected embryos, neonates and adults, with an emphasis on the lymphoid system and gastrointestinal tract. This will suggest when particular tissues or cells become capable of supporting replication, as well as suggesting the normal function of PrP. We are also investigating the innervation of lymphoid tissues and the gut in uninfected mice of different ages and in mouse strains that show differences in responses to peripheral TSE challenge. We are using these models in preliminary investigations of potential therapeutic or prophylactic treatments.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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