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PrP protein: ligand binding and protein-protein interactions
Reference
BBS/E/I/00000632
Principal Investigator / Supervisor
Dr Alan Bennett
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
174,455
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/03/2000
Duration
36 months
Abstract
Previous Surface Plasmon Resonance (SPR) work had shown that CHO cell recPrP binds specifically to immobilised polyanions. Affinity rate constants and binding avidity constants could not be quantified because the kinetics of binding were complex. Attempts to circumvent these problems by immobilising recPrP had been unsatisfactory. The objectives of this project are to use the capture of biotinylated recPrP on streptavidin-coated SPR chips for studies on binding of different PrP protein forms to each other. This may lead to a greater understanding of the species barrier to inter-species TSE transmission.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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