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Award details
Development of non-replicating poxviruses as new and improved recombinant vaccine vectors
Reference
BBS/E/I/00000621
Principal Investigator / Supervisor
Professor Michael Skinner
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
48,990
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/11/1999
Duration
32 months
Abstract
The overall project aim is the further development of safe, improved poxvirus vectors for the expression of foreign antigens, for vaccination of animals and Man. The vectors have the advantage that they will be safer than earlier vaccine vectors, in that they can be used as non-replicating poxviral vectors (NRPVs). New high level promoters to optimise expression of foreign genes by non-replicating poxvirus vectors and to reduce the risk of recombination (thus increasing vector stability) will be developed. Genes from human papilloma virus 16 (HPV-16) and from canine distemper virus will be expressed. Relative levels of foreign antigen expression by the recombinant viruses will be analysed in permissive and non-permissive cell types in vitro.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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