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Characterisation of African swine fever virus-encoded genes which modulate the host immune system

Reference	BBS/E/I/00000618
Principal Investigator / Supervisor	Dr Linda Dixon
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	43,828
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/10/1999
Duration	31 months

Abstract

The African swine fever virus encoded A238L protein functions by two novel mechanisms to interfere with the host response to infection. First, it inhibits activation of transcription dependent on the host NFkB factor and second it binds to and inhibits the cellular phosphatase calcineurin. As a consequence calcineurin dependent pathways such as activation of the NFAT transcription factor are inhibited. The mechanism by which A238L protein functions and its effect on macrophage function are under investigation.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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