Award details

The basis of strain-dependent PrP pathology

Reference	BBS/E/I/00000611
Principal Investigator / Supervisor	Dr Janet Fraser
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	104,808
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1998
Duration	18 months

Abstract

This study examines the effect that route of infection has on the degree and distribution of scrapie pathology in the murine CNS. Computerised image analysis makes it possible to map and quantify the pathological changes that occur throughout the disease process. The routes of experimental challenge (intramuscular and oral) were chosen to mimic the known routes of infection for human growth hormone derived iatrogenic Creutzfeldt-Jakob disease, and the presumably orally transmitted new variant CJD. With the assistance of the CJD Surveillance Unit we have compared these with the pathology in human cases.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search