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Determining the mechanism of neuronal degenerative and its relationship to PrP in scrapie pathogenesis
Reference
BBS/E/I/00000607
Principal Investigator / Supervisor
Dr Janet Fraser
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
114,760
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
03/09/1998
Duration
17 months
Abstract
At present, post-mortem neuropathology and detection of PrPsc are the only methods available to confirm clinical diagnosis of TSE. We intend to use magnetic resonance spectroscopy to determine the anatomical and biochemical changes in the brain associated with TSE. Studies in two different murine models of scrapie, using a combination of in vitro MRS and biochemical techniques will determine whether neuronal loss is a fundamental lesion in the TSEs which gives rise to clinical disease. Neuronal cell death will be correlated with other indices including infectivity and the presence of PrPsc. This study is part of a larger collaboration including MR imaging using the same scrapie models.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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