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Scrapie-associated fibrils and polymeric PrP
Reference
BBS/E/I/00000592
Principal Investigator / Supervisor
Dr Christopher Birkett
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
8,864
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/09/1997
Duration
6 months
Abstract
The most highly purified infectious fractions from scrapie- infected tissues contain an abundance of polymeric PrPSc but also various amounts of non-PrP polypeptides, glycosaminoglycan lipid and nucleic acid fragments. Denaturation of these fractions leads to the depolymerisation of the aggregates and controlled renaturation allows the repolymerisation of these complexes without the loss of infectivity. Experiments will be carried out to determine whether the stoichiochemistry of the components alters during this cycle of denaturation and renaturation and whether the removal of particular components alters the structure of the infectious titre of the infectious fraction complex.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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