Award details

Foot-and-mouth disease virus infection versus phagocytosis

Reference	BBS/E/I/00000518
Principal Investigator / Supervisor	Professor Tom Wileman
Co-Investigators / Co-Supervisors	Dr John Anderson
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	24,550
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1998
Duration	18 months

Abstract

The object of this study is to understand the series of events that lead to the uptake and uncoating of FMDV and eventual delivery of genome into cells. FMDV particles are highly sensitive to acid pH suggesting that the virus is uncoated in endosomes. Lysosomes form the next stage in the endocytic pathway and the hydrolytic environment of the lysosome ensures the ultimate destruction of the virus. Given these observations it is important for the virus to deliver the RNA genome into the cell before transport to lysosomes. The object of this study is to compare virus uptake and genome delivery in endocytically quiescent tissue culture cells such as baby hamster kidney cells and Madin- Darby bovine kidney cells with uptake and processing in primary macrophages: cells which have highly active endocytic and lysosomal pathways.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search