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Peptide-binding specificities of chicken MHC class II molecules

Reference	BBS/E/I/00000454
Principal Investigator / Supervisor	Professor Jim Kaufman
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	3,410
Status	Completed
Type	Institute Project
Start date	01/07/1998
End date	01/07/2001
Duration	36 months

Abstract

Unlike mammals, the response of chickens to certain pathogens and vaccines can depend strongly on the haplotype of the B locus (the chicken MHC). These include antibody responses (for instance, to killed infectious bursal disease virus) which presumably depend on antigen presentation by chicken class II molecules. In order to gain the information needed to understand this phenomenon, certain well-characterised experimental chicken lines are being analysed for the number, genetic location, sequence, expression level and peptide-binding motifs of MHC class II genes and molecules.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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