BBSRC Portfolio Analyser
Award details
Mechanisms of immunity and disease pathogenesis in infections with bovine virus diarrhoea virus
Reference
BBS/E/I/00000453
Principal Investigator / Supervisor
Professor Bryan Charleston
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
580,238
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/03/2000
Duration
36 months
Abstract
Inbred cattle expressing single MHC class II DR haplotypes are being used to characterise antigen recognition to the level of defined peptide binding using recombinant proteins and overlapping synthetic peptides from E2 (gp53) and NS3 (p80). Studies are utilising DR transfectants and analysis of proliferation and cytokine production by helper T-cell lines and clones to distinguish functionally relevant determinants. MHC expression is upregulated on persistently infected cells by a virus-mediated, interferon-independent mechanism and is being examined for possible significance in the pathogenesis of mucosal disease by allowing such cells to present an altered repertoire when superinfected by cytopathic virus.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search