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The persistence of African swine fever virus in the soft tick vector Ornithodoros moubata

Reference	BBS/E/I/00000450
Principal Investigator / Supervisor	Professor Philip Mellor
Co-Investigators / Co-Supervisors	Dr P J Wilkinson
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	6,225
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1997
Duration	6 months

Abstract

African swine fever is a disease of domestic pigs which is caused by African swine fever virus (ASFV), a large icosahedral DNA virus which is the only DNA virus known to be an arbovirus. Its biological vectors are soft ticks of the genus Ornithodoros. The primary objectives of the project are as follows: 1) To study the replication cycle of different strains of ASFV in its soft tick vector, Ornithododros moubata, including identification of the organs and cells in which virus replicates. It is also intended to identify the nature of constraints (barriers) to virus replication and dissemination within the tick. 2) To study the oral, transovarial and transtadial transmission of ASFV via its soft tick host including 3) Confirmation of the occurrence and elucidation of the basis of a novel transmission mechanism of ASFV via its soft tick vectors (co- feeding). 4) Determination of any detrimental effects of ASFV on its soft tick hosts through a comparative study of the oviposition rates, egg hatching rates, moulting rates and mortality rates of infected and uninfected ticks.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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