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CD38 - from molecule to therapy
Reference
BBS/E/I/00000425
Principal Investigator / Supervisor
Dr Michael Parkhouse
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
17,076
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/09/2000
Duration
42 months
Abstract
The lymphocyte membrane protein CD38 is a membrane exoenzyme with the dual functions of degrading NAD (NADASE) and serving as a mitogenic receptor for agonistic antibodies. Of particular interest, its expression is greatly increased in patients infected with HIV that are about to show the advanced clinical symptoms of AIDS. We have now shown that the increased membrane CD38 found in such patients is indeed fully active NADASE, perhaps serving as a scavenger receptor providing nucleotides for DNA synthesis. Finally, reagents have been developed for similar studies of this molecule in cattle.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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