Award details

Characterisation and interactions of an Eimeria tenella protein homologous to coagulation factor XI heavy chain

Reference	BBS/E/I/00000423
Principal Investigator / Supervisor	Professor Fiona Tomley
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	114,112
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1999
Duration	30 months

Abstract

Etmic-5, a protein from the microneme organelles of E. tenella, contains eleven repeated motifs which are structurally similar to the Apple (A) domains of blood coagulation factor XI and plasma prekallikrein. Apple domains are responsible for adhesive interactions mediated by these proteins via specific ligand-binding interactions. Parasite exoxytic organelles contain many proteins and it has been postulated that the active structure which interacts with the host cell may be an aggregate arranged to integrate into a pre- existing plasma membrane. Since Mic5 has a structure which suggests it may bind multiple ligands, this protein may prove to be critical in the invasion process. The aims of this project are to investigate structural and functional aspects of individual domains of the E. tenella protein.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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