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Protective immune response against African swine fever virus
Reference
BBS/E/I/00000410
Principal Investigator / Supervisor
Dr Michael Parkhouse
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
2,134
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/04/1997
Duration
1 months
Abstract
Infection with the avirulent Portuguese non-haemadsorbing tick isolate Ourique/T88/3 of African swine fever virus was found to protect large white/Landrace crossbred pigs and inbred pigs of the dd haplotype from lethal challenge with the related, but virulent, Portuguese tick isolate Ourique/T88/1. When a sub-clinical systemic viraemia was detected, there was always an accompanying rise in the number of circulating CD8hi sub- population. Intra-venous inoculation of ascites fluid containing mouse IgG2a monoclonal antibodies 11/293 or 76/2/11 to total CD8+ porcine lymphocytes abrogated this protection with a correlated depletion of the CD8+ lymphocytes. Analysis of the circulating lymphocytes in the anti-CD8 treated pigs showed all the sub-populations of CD8+ lymphocytes were reduced. These results provide the first definitive evidence for the participation of cellular immunity in resistance to ASFV.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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