Award details

Molecular approaches for improved vaccines against poultry diseases

Reference	BBS/E/I/00000397
Principal Investigator / Supervisor	Dr N Bumstead
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	230,430
Status	Completed
Type	Institute Project
Start date	01/05/1997
End date	30/11/2000
Duration	43 months

Abstract

Although current poultry vaccines have been very successful in controlling the major viral pathogens of poultry this success is threatened by the emergence of new and more virulent forms of several viruses, in particular of Marekthats disease, infectious bursal and infectious bronchitis virus. We have previously shown that the response to vaccination differs in birds of different genotypes, and the contribution of the major histocompatibility complex to these differences in response is now becoming understood at the molecular level. This project seeks to relate the responses of birds of different major histocompatibility complex haplotypes to vaccine strains of infectious bursal disease virus and Marekthats disease virus, and in particular to identify the peptide motifs of these viruses best presented by different genotypes. This be particularly relevant to the new generation of molecular vaccines, where it should be possible to enhance the representation of effective motifs, and also match the vaccines to chicken of well-responding genotypes.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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