Award details

Immunological responses induced by Salmonella in cattle

Reference	BBS/E/I/00000396
Principal Investigator / Supervisor	Professor Bernardo Villarreal-Ramos
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	178,830
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/1999
Duration	24 months

Abstract

Salmonella aro vaccines have been shown to confer solid protection against virulent challenge in several animal species, including cattle. The mechanisms of this protection are unknown. Live attenuated vaccines have also been successfully used as vectors for recombinant antigens, however, most of these studies have been carried out in mice. We have shown that the behaviour of attenuated Salmonella is not the same in mice as in cattle. This appears to correlate with the pathogenesis of Salmonella in the different hosts. Thus, while mice are more susceptible to parenteral than to oral challenge with virulent S. typhimurium, cattle are not. As a consequence, the findings in the small animal model cannot be directly applied to the target species, in this case, cattle. These observations have implications for the design of live attenuated Salmonella vaccines and their use to deliver guest antigens.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search