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Avian B-cell development: pre-bursal cells
Reference
BBS/E/I/00000393
Principal Investigator / Supervisor
Dr Janet Fraser
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
201,130
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/09/1999
Duration
30 months
Abstract
The pre-bursal stages of chicken B-cell development, during which immunoglobulin genes are rearranged, is developmentally restricted and clearly regulated differently than the equivalent stages ion mammals. The aim of this project is to use bacteriophage-display antibody libraries to identify novel cell surface markers expressed during pre- bursal development, that may be involved in its regulation. Different selection strategies with embryonic pre- bursal B- cells have yielded distinct bacteriophage antibodies that all recognise overlapping epitopes. The antigen recognised has a novel pattern of expression during B-cell ontogeny. The antibodies are being used for biochemical characterisation and expression cloning of the encoding cDNA.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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