Award details

Avian B-cell development: differential expression

Reference	BBS/E/I/00000392
Principal Investigator / Supervisor	Dr John Young
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	90,718
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1998
Duration	18 months

Abstract

The chicken is the prototype species in which post- rearrangement diversification of immunoglobulin genes in gut-associated lymphoid organs is an obligate stage of B- cell development. This occurs in the bursa where B-cells proliferate and immunoglobulin genes are diversified by gene conversion. The project aims to identify genes specifically expressed in the bursal stage of B-cell development by using the representational difference analysis method for cDNA subtraction. Libraries of subtracted cDNA have been produced from B-T cell and from bursal cell line - mature B- cell line subtractions. The sequences of distinct cDNAs have been determined and their expression profiles are presently being investigated.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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