BBSRC Portfolio Analyser
Award details
Mechanisms of antigen presentation in chickens
Reference
BBS/E/I/00000391
Principal Investigator / Supervisor
Professor Jim Kaufman
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
170,614
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/09/1999
Duration
30 months
Abstract
In mammals, the TAP, tapasin and LMP genes are all essential for producing, transporting and loading the antigen peptides onto MHC class I molecules. While no LMP genes have yet been identified in chickens, the close linkage of TAP and tapasin genes with the chicken class I genes can lead to co- evolution, which in turn can explain the fact that there is a single dominantly-expressed class I gene. This project investigates the structural and functional polymorphism of the two TAP genes in a number of well-characterised chicken lines, in order to examine the possibility of co-evolution and the effect on the immune response.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search