Award details

Control of Taenia solium & T saginata cystercercosis through specific diagnosis, systemic epidemiology & development of recombinant vaccine candidates

Reference	BBS/E/I/00000387
Principal Investigator / Supervisor	Professor Tom Wileman
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	69,914
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/2000
Duration	36 months

Abstract

This project focuses on the development and application of new diagnostic probes and a recombinant vaccine. Thus genomic and expression libraries of the parasite have been constructed in order to clone parasite antigens of utility in diagnosis and protection. To date four potentially protective oncospheral antigens have been cloned, sequenced and expressed for evaluation in diagnostic and protection assays. Their sequence has also provided an alternative, and promising, route via synthetic peptides. These peptides are also currently being evaluated in protective and diagnostic assays. Finally, parasite specific genomic clone sequences have been selected and sequenced in order to provide the necessary information for the construction of species specific PCR assays for Taenia saginata and Taenia solium. These tests will have a major impact on the control of these two important parasites of man, pigs and cattle.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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