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Award details
Effect of African swine fever infection on pig macrophage function
Reference
BBS/E/I/00000320
Principal Investigator / Supervisor
Dr Penelope Powell
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
755,593
Status
Completed
Type
Institute Project
Start date
01/07/1997
End date
30/06/2000
Duration
36 months
Abstract
African Swine Fever (ASF) virus has a strict tropism for macrophages. The virus evades immune surveillance and causes a fatal hemorrhagic disease of domestic pigs. Macrophages play an important role in the immune response and are important regulators of vascular haemostasis. The goal of this project is to determine how changes in cytokine gene expression induced by the virus can explain the neutralisation of the anti-viral defences of the macrophage, and how regulatory protein such as cytokines and pro- coagulatory factors secreted by macrophages in response to infection cause fatal hemorrhagic pathology.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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