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Cytokines as modulators of immune responses in cattle
Reference
BBS/E/I/00000311
Principal Investigator / Supervisor
Professor Christopher Howard
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
302,111
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/03/2000
Duration
36 months
Abstract
The central role of cytokines in the regulation and control of the immune response makes them a prime target for exploitation in strategies aimed at inducing effective immunity to microbial pathogens. An initial stage of investigations of immunity requires an ability to analyse cytokines in vaccinated or infected animals and assays for cattle cytokine mRNA and proteins have been established. The use of immunoregulatory cytokines in vaccination strategies is now being developed. Initial studies have focussed on IL-12, produced by antigen presenting cells and a key cytokine in the regulation of the type 1 several type 2 helper T cell responses. Its role on the bias of the T cell response of cattle is being defined and its possible use as an immunomodulatory adjuvant explored.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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