Award details

MHC-encoded genes and T-cell functions

Reference	BBS/E/I/00000310
Principal Investigator / Supervisor	Professor Shirley Ellis
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	263,008
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/2000
Duration	36 months

Abstract

Inbred cattle expressing single MHC class I haplotypes are being used to assess the functional implications of observed variations in class I expression. Detailed analysis of complete class I haplotypes (including gene cloning, sequencing and expression studies) is ongoing. T cell response studies in relation to pathogens such as bovine RSV and Theileria parva are utilising MHC class I molecules characterised to the level of peptide binding capability. MHC transfectants are used in various capacities to determine the specificity of CTL clones, which can allow identification of suitable pathogen encoded proteins for incorporation into vaccines.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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