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Mechanisms behind host specificity of bacteria, investigated by use of host-specific Salmonella serotypes
Reference
BBS/E/I/00000302
Principal Investigator / Supervisor
Dr Timothy Wallis
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
331,627
Status
Completed
Type
Institute Project
Start date
01/05/1997
End date
30/04/2001
Duration
48 months
Abstract
The overall objective is to establish the basis for utilising host range determining factors of bacteria as a means for controlling disease. The specific objectives are, first, to identify and characterise the factors responsible for host-specificity of selected Salmonella serotypes. Second to probe the pathogenicity of the host specific serotypes in their relevant hosts and in other animal species to identify at what stage of the infection process that the host specific phenotype is expressed. Third, using signature tagged transposon mutagenesis, identify genes influencing host specificity. Fourth to study the host immune response to infection and to investigate if challenged animals are protected against challenge with other host specific serotypes. Finally, based on the results to evaluate whether host-range determining factors can be used to control salmonellosis.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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