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Expression of bovine MHC
Reference
BBS/E/I/00000297
Principal Investigator / Supervisor
Professor Shirley Ellis
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
39,760
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/09/1999
Duration
30 months
Abstract
A method for accurately assessing numbers of cell surface expressed molecules (using quantitative flow cytometry) has been optimised, and used to examine expression of different cattle MHC class I genes. Consistent differences in the relative expression levels of class I genes have been observed, which are maintained during upregulation resulting from infection, or treatment with cytokines. Transcriptional control mechanisms are being investigated by sequencing the 5' upstream region of a number of class I genes. This study has utilised BAC clones (see 109/286) containing both classical and uncharacterised class I genes, and will lead to a greater understanding of their relative functional significance.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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