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Immune approach to bovine respiratory syncytial virus control: importance of dendritic cells for induction of T-cell responses and vaccine design

Reference	BBS/E/I/00000294
Principal Investigator / Supervisor	Professor Christopher Howard
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	16,097
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/10/1998
Duration	18 months

Abstract

Respiratory syncytial virus is a major cause of respiratory infection in young calves. A similar infection occurs in young children. Published data suggests that the virus, or its antigens, may produce in an inappropriate bias in the resulting T cell response for immunity. Primary immune responses in naive animals are initiated by dendritic cells. Any effect of the virus on the ability of these cells to stimulate a T cell response could be critical for subsequent immunity. This project is investigating the way in which the virus is taken up by dendritic cell and the effect of the virus on the cytokines produced by the antigen presenting cell.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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