Award details

MHC transcription in equine pregnancy

Reference	BBS/E/I/00000291
Principal Investigator / Supervisor	Professor Shirley Ellis
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	30,790
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1998
Duration	18 months

Abstract

Control of MHC expression on foetally-derived trophoblast is acknowledged to be one of the factors which enable an MHC incompatible foetus to be tolerated by the maternal immune system. In horses, as in cattle, most trophoblast cells are MHC negative. However a population which form a structure termed the chorionic girdle (approx. day 25 of pregnancy) exhibit high surface levels of MHC class I for a defined period of time (approx. 10-20 days). These cells can be isolated and cultured from flushed 33 day conceptuses, and provide a useful model for studies of MHC gene regulation. The nature of the MHC genes expressed (i.e. classical/non- classical) in chorionic girdle cells is currently being investigated, using locus- and allele-specific PCR primers, and locus-specific mAbs.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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