Award details

Mapping bovine MHC class I genes

Reference	BBS/E/I/00000286
Principal Investigator / Supervisor	Professor Shirley Ellis
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	41,813
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1998
Duration	18 months

Abstract

Variation in MHC class I haplotype composition in cattle is likely to be functionally significant. It is not clear whether all genes are always present (but some are not transcribed), or alternatively whether most haplotypes do not carry the full complement of class I genes. A bacterial artificial chromosome (BAC) library, consisting of ~40,000 clones, made with DNA from a MHC-homozygous animal has been analysed in order to address this question. Seven out of a detected 20 MHC class I-positive clones form a contig which encompasses the 3 expressed class I genes on this haplotype, together with a number of additional class I-like genes. Detailed mapping of these, and other genes within the MHC region e.g. TAP, LMP is currently underway.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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