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Award details
Structure and function of the avian MHC
Reference
BBS/E/I/00000285
Principal Investigator / Supervisor
Professor Jim Kaufman
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
277,791
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/08/1998
Duration
17 months
Abstract
In stark contrast to the mammalian MHC exemplified by humans and mice, the chicken MHC can determine striking resistance and susceptibility to certain infectious pathogens as well as response to vaccines. In this project, the structural and functional basis of these phenomena have been examined. This has included 1. sequencing a chicken MHC haplotype (92 kB of the B locus of the B12 haplotype), 2. characterisation of various genes and gene products from the MHC, 3. mapping other relevant genes in the chicken genome, and 4. analysis of peptides derived from pathogens that bind particular MHC molecules.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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