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The cell biology of African swine fever virus

Reference	BBS/E/I/00000271
Principal Investigator / Supervisor	Professor Tom Wileman
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	6,049
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/04/1997
Duration	1 months

Abstract

African Swine Fever (ASF) virus is a large icosahedral enveloped DNA virus that causes a fatal haemorrhagic disease of domestic pigs. The virus is 200nm in diameter with a central nucleoprotein core surrounded by protein matrix, lipid envelopes and capsid. We have designed cell biological assays to determine the mechanism of recruitment of capsid proteins into the virion. The major capsid proteins are synthesised in the cytosol and then bind to the cytosolic face of the endoplasmic reticulum (ER). During the next hour capsid proteins oligomerise into large complexes suggestive of capsid or matrix precursors with kinetics similar to envelopment. Both processes are energy dependent and are regulated by the ER Ca++ store and cellular redox potential.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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