Award details

Development of a genetically marked rinderpest vaccine

Reference	BBS/E/I/00000259
Principal Investigator / Supervisor	Professor Thomas Barrett
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	30,020
Status	Completed
Type	Institute Project
Start date	02/10/1997
End date	01/10/1998
Duration	12 months

Abstract

The purpose of this project is to produce a genetically defined and marked rinderpest virus, attenuated in cattle and other ruminants, and capable of inducing a protective immune response to challenge with highly pathogenic strains of rinderpest virus. The inserted marker should produce a strong humoral antibody response in vaccinated animals capable of being detected by a simple ELISA system which will be developed for this purpose. A marked vaccine would have an enormous impact on the efforts of the PARC campaign to eliminate rinderpest from Africa, since it would then be possible to distinguish vaccinated from naturally infected animals. Mild strains of the disease are making it difficult to locate foci of infection by clinical observation and vaccination masks its presence in serosurveillance studies.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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