Award details

Pathogenesis, cross-species infectivity and immunogenicity of morbilliviruses

Reference	BBS/E/I/00000258
Principal Investigator / Supervisor	Professor Thomas Barrett
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	33,030
Status	Completed
Type	Institute Project
Start date	01/03/1998
End date	01/03/2001
Duration	36 months

Abstract

An alternative approach to new vaccine development is to exploit the advantages of RPV, especially the long duration of the immune response generated to this virus, and use it as a vector to express immunogens from other viruses. A major question in viral immunology is whether there is antigenic (protein) persistence in antigen presenting cells or whether genome persistence is required for the generation of long lived immune responses. Such recombinant vaccines, expressing individual virus proteins from other pathogens, will be used to study in greater detail the humoral and cellular responses to virus infection and the role the individual proteins play in generating lasting protective immune responses. Another important question being addressed is; what barriers exist to virulent infection by a morbillivirus in a non-natural host species? Little is known concerning factors that prevent morbilliviruses jumping the species barrier; RPV and PPRV only cause disease in artiodactyls, CDV mainly causes disease in carnivores while MV only causes disease in primate hosts. Chimeric viruses, in which the glycoproteins of CDV, RPV and PPRV are swapped, will be made in order to study the effect of these changes on the potential of these viruses for replication and spread in the natural host of each virus. The role the glycoproteins play in allowing or preventing virus replication in different tissues within the same host will also be studied.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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