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Molecular mechanisms of fowlpox virus replication and host interaction
Reference
BBS/E/I/00000257
Principal Investigator / Supervisor
Professor Michael Skinner
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
364,480
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/03/2000
Duration
36 months
Abstract
This study of the complex fowlpox virus focuses on two major areas. One is a comparison of the assembly of fowlpox virus in permissive avian cells with the abortive assembly in mammalian cells, which are non-permissive. The other area is the role, in virus replication and survival, of unusual fowlpox homologues of cellular genes, especially the homologues of glycoprotein PC-1 (an exo-nucleotide phosphodiesterase), SNAP (involved in vesicle transport of proteins) and DNase II. The work will involve homologous over-expression of native and tagged proteins and generation of virus knock-out mutants by recombination.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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