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Antigenic structure of infectious bursal disease virus

Reference	BBS/E/I/00000255
Principal Investigator / Supervisor	Professor Michael Skinner
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	151,507
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/2000
Duration	36 months

Abstract

Within recent years, infectious bursal disease (IBD; Gumboro disease) has twice posed serious threats to the poultry industry world-wide. In order to predict the nature of antibody resistance mutations that may be selected in practise, precise antigenic epitopes need to be identified. This will be performed by the isolation of MAbs, neutralising and non-neutralising, against the VV strain of IBDV (isolate UK661) which we have recently sequenced. Neutralising MAbs will then be used to isolate mutants of tissue-culture adapted UK661 (which will have been sequenced through the antigenic sites). The mutants will then be sequenced to identify mutations responsible for resistance to the MAbs.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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