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Novel mechanisms of live, bacterial vaccines in protection against Salmonella and other food-borne zoonoses (A)
Reference
BBS/E/I/00000246
Principal Investigator / Supervisor
Professor Paul Barrow
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
83,760
Status
Completed
Type
Institute Project
Start date
01/04/1999
End date
31/03/2002
Duration
36 months
Abstract
When very young animals are inoculated orally with an avirulent Salmonella vaccine strain the bacteria multiply extensively to high numbers and confer resistance to re- infection and to clinical disease by wild-type strains by two completely separate mechanisms. The first, observed in newly-hatched chickens and in young gnotobiotic pigs, is a microbiological phenomenon which is connected to the down- regulation of growth observed in stationary-phase nutrient broth cultures. The second, observed only in pigs, is a rapid stimulation of non-specific immunity which, in the experimental system studied, prevented diarrhoea despite the presence of very high numbers of virulent Salmonella bacteria in the gut. A network of European laboratories has been involved in this research for some time and with co- ordination by P. Barrow (IAH, Compton) substantial shared cost research funding has been obtained under Framework Programme IV to study the basic and practical aspects of these phenomena.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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