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Award details
Mechanism of immunity to food-poisoning and vaccine serotypes of Salmonella in chickens
Reference
BBS/E/I/00000245
Principal Investigator / Supervisor
Professor Paul Barrow
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
926,502
Status
Completed
Type
Institute Project
Start date
01/12/1999
End date
31/05/2005
Duration
66 months
Abstract
An extensive collaboration has been set up between IAH, Compton and the University of Cambridge to begin to define the nature of immunity to Salmonella in chickens. It is known that a strong immunity to reinfection can follow infection with S. typhimurium or S. enteritidis. In addition it is well know that some serotypes can be carried in the tissues for many months without elimination. To assist in the development of live, attenuated vaccines in a non-empirical way we setting up several research groups at both sites to begin to elucidate the mechanisms of immune function in chickens infected with wild-type and vaccine strains of Salmonella. This involves, defining the nature of the cellular responses following intestinal and systemic infection, elucidating the nature of the response and defining the role of dendritic cells.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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