Award details

Molecular and functional characterisation of avian chemokines

Reference	BBS/E/I/00000242
Principal Investigator / Supervisor	Dr N Bumstead
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	277,810
Status	Completed
Type	Institute Project
Start date	01/10/1998
End date	30/09/2001
Duration	36 months

Abstract

We have recently isolated clones of three novel chicken chemokines: these molecules are the central messengers of the immune system and their isolation opens new possibilities for understanding and manipulating the avian immune system. This project aims to characterise the function of these genes, compare them to their mammalian equivalents and use them as tools to identify further chemokines. The three genes will be fully sequenced and their position mapped within the chicken genome. The genes will be expressed in the baculovirus system to provide material for in vitro and in vivo assays of their function and also to generate antibodies. With these tools it should be possible to define the cell types they attract and assess induction of the chemokines at the RNA and protein level following infection.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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