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Cell biology of African swine fever virus assembly

Reference	BBS/E/I/00000226
Principal Investigator / Supervisor	Professor Tom Wileman
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	93,398
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1999
Duration	30 months

Abstract

African Swine Fever (ASF) virus is a large icosahedral enveloped DNA virus. The virus is 200nm in diameter with a central nucleoprotein core surrounded by protein matrix, lipid envelopes and capsid. We are interested in the cell biological mechanisms that control the assembly of this highly complex virus. Assembly takes place in specialised perinuclear subcompartments of the cell called viral factories. Factories organise host cell membranes and recruit cellular proteins and both structural and non- structural viral proteins from the cytosol. After a lag period of 12 hours fully assembled particles, but not assembly intermediates, are released into the cytoplasm. We are determining the origins of the cellular membranes recruited into factories and the mechanism of assembly of the viral capsid and matrix layers within viral factories.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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