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Biological properties of a viral I B homologue
Reference
BBS/E/I/00000225
Principal Investigator / Supervisor
Dr Penelope Powell
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
70,591
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/09/1999
Duration
30 months
Abstract
African Swine Fever (ASF) virus is a large DNA virus that causes a fatal haemorrhagic disease of domestic pigs but a persistent infection in the African bushpig and warthog. The genome of ASF virus encodes a gene (A238L) with homology to IkB, a cellular inhibitor of the transcription factor NFkB. NFkB plays a central role in the modulation of the macrophage proinflammatory immune response and we have been investigating if the A238L gene product A238Lp inhibits the function of NFkB. Transfection experiments show that A238Lp binds the p65 subunit of NFkB and inhibits the pro- inflammatory response of macrophages. The A238L protein may be act as a dominant negative inhibtor of NFkB, and modulate the proinflammatory immune response during infection.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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