Award details

Intracellular responses to virus infection

Reference	BBS/E/I/00000217
Principal Investigator / Supervisor	Professor Graham Belsham
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	78,078
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1999
Duration	30 months

Abstract

Within cells infected with picornaviruses such as foot-and- mouth disease virus or poliovirus the translation of most cellular mRNAs is severely inhibited since the translation initiation factor complex, eIF4F which binds to the 5' terminal cap structure of mRNAs, is cleaved by virus encoded proteins. The picornavirus RNA and certain cellular mRNAs are translated by a cap- independent mechanism which requires an internal ribosome entry site (IRES). A selection system for functional IRES elements has been developed and this has permitted the isolation of novel functional IRES elements. An alternative application of the same system has permitted the demonstration that vaccinia virus mRNA translation has a low requirement for eIF4F.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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