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Functional analysis of the role of microneme organelles in host cell recognition

Reference	BBS/E/I/00000213
Principal Investigator / Supervisor	Professor Fiona Tomley
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	119,785
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1997
Duration	6 months

Abstract

The abundant microneme protein EtMic1 contains two independent structural domains that may have functional significance. The 'I- domain', is conserved in several molecules of known adhesive function and has been shown to be important in numerous extracellular protein- ligand interactions. The thrombospondin (TSP) type I repeats are also conserved in a number of adhesive molecules and recently have been shown to mediate binding of malaria sporozoites to hepatocytes via heparan sulphate proteoglycans. This project will investigate whether the two domains of Mic1 are capable of binding specific ligands on the host cell surface

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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