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Cloning of the chicken interleukin-6 homologue and its role in immune response to coccidial infection

Reference	BBS/E/I/00000211
Principal Investigator / Supervisor	Professor Peter Kaiser
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	23,604
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1997
Duration	6 months

Abstract

The production of IL-6 during Eimeria infection in both birds and mice was investigated. Two bioassays were used to detect chicken IL-6-like factors in supernatants (s/n) from chicken fibroblasts, macrophages and splenocytes. In addition, the presence of IL-6-like factors was detected in serum taken from chickens infected with the highly pathogenic/moderately immunogenic E. tenella, but not sera from those infected with the moderately pathogenic/highly immunogenic E. maxima. Systemic and local IL-6 production during E. vermiformis infection was also investigated, in resistant BALB/c, and susceptible C57BL/6, mice, using a murine IL-6 ELISA and bioassay. Enhanced/earlier systemic production of IL-6 in serum was seen in infected BALB/c mice compared to C57BL/6 mice. This difference was also reflected at the local level, in s/n from stimulated mesenteric lymph nodes.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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