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Virus pathogenesis: a reverse genetic approach to study the determinants of pathogenicity of rinderpest virus
Reference
BBS/E/I/00000199
Principal Investigator / Supervisor
Professor Thomas Barrett
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
26,880
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/03/1999
Duration
24 months
Abstract
The current vaccine strain of rinderpest virus (RBOK) was isolated from a highly pathogenic strain (KO) by serial passage. Both strains are available and have been sequenced. Using the technology we have developed to rescue live rinderpest virus from cDNA clones of the viral genome, we are creating chimeras of virulent and non-virulent strains to identify those genetic changes responsible for the difference in phenotypes.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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