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Role of ubiquitin during African swine fever virus infection
Reference
BBS/E/I/00000185
Principal Investigator / Supervisor
Dr Linda Dixon
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
50,891
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/09/1998
Duration
18 months
Abstract
Post-translational modification of proteins by covalent attachment of the short polypeptide, ubiquitin occurs by a multistep process in all eucaryotic cells. The main consequence of protein ubiquitination is to target proteins for proteolysis by the proteasome and this is involved in regulating diverse processes such as cell cycle progression and gene transcription. The ubiquitin conjugating enzymes determine substrate specificity to a large extent. ASFV encodes the only known virus UBC enzyme (UBCv) and this might be involved in regulating some aspect of virus replication or may modulate host cell function by targeting specific proteins for proteolysis. The aim of the project is to study the role of ubiquitin in virus replication by studying the function of the virus encoded UBC enzyme.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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