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Award details
Secreted virulence-associated proteins of Salmonella
Reference
BBS/E/I/00000177
Principal Investigator / Supervisor
Dr Edouard Galyov
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
816,482
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/03/2001
Duration
48 months
Abstract
The invasion of Salmonella into epithelial cells is an essential feature in pathogenesis. Inv/spa loci of Salmonella are required for the expression of the invasive phenotype. Structural features of inv/spa gene products suggest their involvement in the export of Salmonella- specific effector molecules and their delivery to sites of interaction with the eukaryotic cell. The aim of this study is to identify, characterise, and determine the role(s) of Salmonella secreted proteins in virulence using cultured eukaryotic cells as a model system to elucidate mechanisms disease development and methods by which Salmonella obstructs the primary host defence. This project is to investigate Salmonella proteins that are likely to be involved in invasion of host cells and the control of intracellular growth and survival of the bacteria. Salmonellosis remains an important human and animal health problem. Research on molecular mechanisms of Salmonella - host cell interactions will generate the new information needed to assist in developing better methods for the control of the disease and the identification of new targets for pharmaceutical products.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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