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Mechanisms involved in the invasiveness of S. typhimurium and S. dublin for cattle

Reference	BBS/E/I/00000147
Principal Investigator / Supervisor	Professor Paul Barrow
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	1,537
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/04/1997
Duration	1 months

Abstract

The virulence of S. dublin, S. choleraesuis, S. gallinarum and S. abortusovis strains were compared following oral and intravenous inoculation of calves and pigs. S. choleraesuis caused severe enteric and systemic disease in both calves and pigs. S. dublin caused systemic and enteric disease in both calves and pigs. S. gallinarum and S. abortusovis were avirulent in both host species. The ability of these serotypes to invade bovine ileal mucosa and to induce an enteropathogenic response were compared. All serotypes were highly invasive and there were no differences in the recovery of salmonellas from tissue with or without Peyer's patch. All serotypes induced an enteropathogenic response with the exception of S. abortusovis although the intensity of this response varied. There was no overall correlation between invasion of intestinal epithelia or the induction of an enteropathogenic response with Salmonella-serotype-host specificity.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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