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The molecular determinants of enhanced virulence of a pathotypic variant of the birnavirus, infectious bursal disease virus

Reference	BBS/E/I/00000094
Principal Investigator / Supervisor	Professor Michael Skinner
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	4,648
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1997
Duration	6 months

Abstract

Following the determination of the complete coding sequences of both genome segments of UK 'very virulent' (VV) IBDV 661, a detailed analysis was performed to identify mutations that might be involved in the enhanced virulence of the VV strain. The VP4 protease of UK661 is highly diverged and the IBDV VP4 protease active site (and indeed polyprotein cleavage sites) has not been mapped. Detailed sequence comparison and analysis has revealed the likely location of the active site, showing that there is an adjacent substitution in UK661. There is also a substitution adjacent to a candidate polyprotein cleavage site. This project will now concentrate on localising the protease active site and the polyprotein cleavage sites. The affect on polyprotein processing, of the substitutions seen in UK661, will then be examined.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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