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Internal initiation of translation in yeast
Reference
BBS/E/I/00000079
Principal Investigator / Supervisor
Professor Graham Belsham
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
38,246
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/09/1997
Duration
6 months
Abstract
In eukaryotic systems the initiation step of protein synthesis is usually highly dependent on the recognition of the 5' terminal cap- structure on mRNAs. However in recent years it has become apparent that picornaviruses, like foot- and-mouth disease virus and poliovirus, plus certain other viral and cellular mRNAs use an alternative mechanism for initiation dependent on the presence of a complex RNA structure termed an internal ribosome entry site (IRES). This project aimed to utilise yeast genetics to analyse factors involved in internal initiation of protein synthesis. It now appears that S. cerevisiae does not use internal initiation. However, the 5' non-coding region of a mRNA from the fission yeast S. pombe can direct internal initiation within mammalian cells and within cell free systems, the properties of this element have been characterised.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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