Award details

RNA-protein interactions relevant to bluetongue virus replication

Reference	BBS/E/I/00000059
Principal Investigator / Supervisor	Dr Andrew Metaxas
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	2,500
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/04/1997
Duration	1 months

Abstract

This is a BBSRC funded link project with Professor Polly Roy at the University of Oxford. Baculovirus expression systems have been used to produce bluetongue virus (BTV) proteins, either individually, or as the components of a synthetic core like particle. These proteins and particles are being used to study the interaction of viral RNA with the structural and enzymatic protein components of the virus during replication. Using systems initially developed with native BTV core particles as a control, the project will analyse transmethylase 1 and 2 as well as guanylyl transferase activities, and their role in capping exogenous viral mRNA. We have already been able to assign these enzyme functions to the minor core protein VP4. The polymerase function that is vital for virus assembly and replication is also being studied using these systems.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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